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Most strikingly, it was found that administration of either MV8608 or MV8612 caused a significant reduction in the nociceptive responses
The exact mechanism with which this occurs is unclear, but it is suspected that neural factors play a key role in this mechanism
Variability Across Study Designs Safety signals in published studies vary due to differences in: species used (rodents vs other models) dosing magnitude route of administration model type (injury-induced vs healthy tissue) study duration This variability limits the ability to draw broad conclusions
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