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Importantly, loss of GSTP1 expression in the cisplatin-resistant A2780 subline A2780DPP was toxic to the cells in the presence of cisplatin, consistent with an important catalytic role for GSTP1 in glutathione conjugation in the detoxification pathway of platinum drugs
Lo HW, Ali-Osman F
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Abstract Kidney diseases refer to a group of disorders that affect the structure and function of the kidneys, impairing their ability to filter waste products, excess fluids, and toxins from the blood
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