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Increased frequency of dual-positive TH2/TH17 cells in Bronchoalveolar lavage fluid characterizes a population of patients with severe asthma
Peter de Keizer's pioneering research at Erasmus University Medical Center to its current status as a leading senolytic research tool, FOXO4-DRI demonstrates how precise molecular targeting can enable selective elimination of harmful cellular populations while preserving healthy tissue function
The FOXO4p53 axis in senescence p53 is a major tumour suppressor and master regulator of cellular stress responses: DNA damage, oxidative stress, oncogene activation
Hence, senolytic therapies may be a suitable approach for increasing therapy sensitivity and preventing cancer relapse 10
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