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Some people notice improvements within a few weeks, while others may require several months of consistent treatment
Furthermore, we identified the sources of the metabolites and found 23 metabolites from the host, 85 metabolites from the microbiota, 198 metabolites from host-microbiota cometabolism, and 876 metabolites from others, which consisted of drug (128), food (348), environment (9), and unknown (391) (Fig
Thus, master protocol designs, such as umbrella trials, basket trials, and adaptive platform trials, are gaining prominence
Higher doses are not recommended, as theres no evidence that they provide extra benefits
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