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Wang, J., Yadav, V., Smart, A

Compared with the structure of human GLP-1(7-37), the amino acid sequence of dulaglutide contains glycine at position 8, glutamic acid at position 22, and glycine at position 36

Animal studies utilizing acute stress models have shown that in mice stress-induced BBB permeability reduces the pyridostigmine dose required to inhibit brain acetylcholinesterase by 50% to less than 1/100th of the usual dose used (Friedman et al, 1996)

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