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The National Heart, Lung and Blood Institute Heart Failure Clinical Research Network designed the Functional Impact of GLP-1 for Heart Failure Treatment (FIGHT) study (NCT01800968) to test the hypothesis that liraglutide would improve myocardium bioenergetics leading to post-hospitalization clinical stability in subjects with advanced HF and reduced left ventricular ejection fraction, with and without diabetes [47]

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Quick Answer: Shortness of breath is not a recognized direct side effect of GLP-1 medications, though respiratory symptoms may occur through indirect mechanisms such as severe gastrointestinal complications, dehydration, or rare allergic reactions