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A systematic review reported that sitagliptin effectively reduces HbA1c levels from baseline with a favorable side effect profile compared to many other antidiabetic medications, making it an effective choice for long-term glycemic control

While pharmacological agents, natural products, and gene or cell therapies have demonstrated efficacy in preclinical studies, their clinical relevance depends on identifying actionable targets, suitable patient populations, and potential integration with existing therapies

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In addition, careful control of the free water content within the hydrogel is essential to minimize HER