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This is especially important considering the increasing use of these medications. The authors write that, to their knowledge, this is the first case detailing a patient developing this serious condition after starting tirzepatide for diabetes (in contrast to those treated with tirzepatide for weight loss)

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More potent than its predecessors, retatrutide activates three receptorsGLP-1, GIP, and glucagonas opposed to only one (as is the case with semaglutide) or two (like tirzepatide)