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This third pathway (glucagon) differentiates retatrutide from combination approaches like CagriSema
That's why Novo Nordisk sees it as only the beginning of a much bigger, longer-term assault on obesity
Development of Glucagon-Like Peptide 1 Receptor Agonists for the Management of Obesity Glucagon-like peptide 1 receptor agonists (GLP-1RAs), including liraglutide and semaglutide, were initially developed for the treatment of type 2 diabetes but were found to be effective not only in reducing blood glucose levels but body weight as well [18,19,20]
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