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In clinical trials of adults without diabetes (SURMOUNT-1), patients treated with tirzepatide for chronic weight management lost an average of 1521% of their body weight over 72 weeks, depending on the dose used
Poor brain function in people with liver failure (hepatic encephalopathy)
Metformin Use with GLP-1 RA: Synergy Towards Better Outcomes Metformin with GLP-RA Effect on Weight-Lowering Response: A 52-week prospective study including 194 obese T2D patients showed concomitant initiation of metformin alongside GLP-1 receptor agonist therapy is associated with enhanced weight loss efficacy, suggesting a potential synergistic metabolic interaction that improves the likelihood of achieving clinically meaningful weight reduction
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