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Only, SAMe and B-vitamins co-supplementation resulted in most pronounced attenuation of ethanol-induced pathological features, as evidenced by improved hepatocyte morphology, preserved sinusoidal structure, and a near-normal appearance of the portal triad
doi:10.1111/j.1365-313X.2007.03280.x
This process is partly mediated by the upregulation of brain-derived neurotrophic factor (BDNF), a neurotrophin that promotes neuronal survival, synaptic plasticity, and functional connectivity, ultimately supporting memory consolidation and executive function [77]
In the same region, MDD was associated with an upregulation of genes in the astrocytic branch (KYAT1, AADAT) and the glutamate transporter EAAT2 [66]
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