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Transcutaneous Electrical Nerve Stimulation and Pain With Movement in People With Fibromyalgia: A Cluster Randomized Clinical Trial

Problems with the kidneys There have been reports that taking high doses of glutathione for a long time can put stress on the kidneys or make them toxic, especially if you dont drink enough water or get enough assistance

The uneven weekly rhythm can cause confusion

Similarly, although hepatic dysfunction can occur with large niacin doses (1-3 grams daily over months) causing elevated liver enzymes or jaundice, niacinamide at 100 mg is very unlikely to have any adverse effect on the liver