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Collection of fractions every 10-30 min for LC-MS/MS or HPLC quantification
In vivo xenograft model experiments have shown that injection of RGD-modified sEVs carrying miR-484 can induce vascular normalization, thereby sensitizing cancer cells to chemotherapy-induced apoptosis [211]
A multicellular tumor spheroid is a tissue culture model that mimics the pathological conditions of solid tumors including a three-dimensional cellular structure, nutrition, and proliferation gradients
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