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Top left: VX originated from organophosphate pesticide research in the 1930s1950s and was later adapted for military applications

It must also feel pleasant on the skin, absorb smoothly, and remain stable throughout its shelf life

Other miscellaneous conditions were also excluded, including excessive consumption of grapefruit, as well as possible interactions withdrug intake (antiarrhythmics, sympathomimetics, parasympatholytics, enzyme inducers, enzyme inhibitors, and antioxidants)

Any diagnostic or therapeutic inference drawn from the group-level GSH reduction therefore remains hypothesis-generating, and would need to be confirmed in larger, independent cohorts using longitudinal designs and ideally more objective indices of disease activity, such as prospective headache diaries or attack-phase measurements