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Initially, it seemed improbable to screen over 3,000 analogs only to discover a compound operating through the well-established effector, CRBN, especially one with minimal independent affinity for the ligase

That might mean focusing more on lifestyle changes, switching medications, or considering bariatric surgery. For some patients, surgical options such as sleeve gastrectomy may be appropriate, particularly if they want a more durable intervention

Its essential to avoid situations that use up lots of energy (like fasting) as that can trigger the condition

Animals were housed under a 12:12 h light/dark cycle at 2224 C