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When we speak about obesity, were looking at a multi-disciplinary approach that includes behavioral interventions, lifestyle modifications, and pharmacology, says Raj Dasgupta, MD, a board-certified physician and associate professor of clinical medicine at the University of Southern California in Los Angeles

Before starting treatment, healthcare providers should obtain baseline blood pressure measurements in both sitting and standing positions to identify pre-existing orthostatic hypotension

Additionally, disruptions in the blood-brain barrier in those with neurocognitive symptoms have been observed, as well as hypoperfusion in various organs, contributing to end-organ dysfunction [364, 365]

Its about reducing body fat while preserving the lean muscle that supports a healthy metabolism