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In mouse models of insulin resistance, it significantly inhibits NNMT activity in liver and muscle, reduces NAM methylation, increases intracellular NAD+, activates the SIRT1 pathway, promotes phosphorylation of insulin receptor substrate 1 (IRS1), enhances insulin signaling, improves insulin sensitivity, and increases glucose uptake and utilization
Structure Chemical Name: 5-Amino-1-methylquinolinium Molecular Formula: CHN Molecular Weight: ~158.20 g/mol Compound Class: NNMT Inhibitor PubChem CID: Not yet assigned Citations for 5-Amino-1MQ Kraus, D., et al
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