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Under physiological conditions, GSH quenches oxidizing substances (such as reactive hydroxyl free radicals, peroxynitrite, and H 2 O 2 ) directly or reduces hydrogen peroxide (or lipid peroxide (lipid-OOH)) to water (or the corresponding lipid alcohol (lipid-OH)) under the catalysis of GPX (summarized in Fig
This conversion directly supports mitochondrial bioenergetics, leading to higher adenosine triphosphate (ATP) levels in hepatocytes (liver cells) and preventing the mitochondrial dysfunction that often accompanies severe toxic burden
The most common side effects are gastrointestinal, including nausea (occurring in 20-30% of patients), diarrhea, vomiting, constipation, and abdominal discomfort
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