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doi: 10.3389/fphar.2020.579944 Received 03 July 2020 Accepted 15 September 2020 Published 07 October 2020 Volume 11 - 2020 Edited by Leonello Fuso, Catholic University of the Sacred Heart, Italy Reviewed by Stephen C

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HA-CS nanocomplexes loaded with siRNA could penetrate the rabbit vitreous, and following intravitreal injection, a reduction in laser-induced neovascularization in the rabbit retina was observed, accompanied by good tolerability, biosafety, and enhanced bioavailability [32]