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In 2022, updated Kidney Disease: Improving Global Outcomes (KDIGO) clinical practice guidelines recommended SGLT2i as first-line therapy for patients with estimated glomerular filtration rate (eGFR) 20 mL/min/1.73 m 2 (previously 30 mL/min/1.73 m 2 ) and GLP-1 RA as an additional therapy option for patients with insufficient glycemic control as part of a comprehensive risk-reduction approach for people with type 2 diabetes and CKD [5, 6, 14]
Omega-3 supplements at high doses (typically above 3g daily) may increase bleeding risk, particularly in individuals taking anticoagulants (such as warfarin) or antiplatelet agents (such as aspirin or clopidogrel)
GLP-1 receptor agonists are large protein molecules exceeding 3,000 Daltons in molecular weight, far above the 500 Dalton threshold for effective passive skin penetration
Vitamin C plays a role in glutathione recycling
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