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Severe vomiting can lead to dehydration and acute kidney injury in some cases
10.1074/jbc.M114.550574[Epub ahead of print]
Energy Expenditure and Thermogenesis GLP3s glucagon receptor activation specifically contributes to increased energy expenditure through multiple pathways[6]: Enhanced hepatic fatty acid oxidation and lipolysis Increased thermogenic activity in brown adipose tissue Upregulation of uncoupling protein expression Potential FGF21-mediated metabolic effects This thermogenic component distinguishes the blend from pure GLP-1 or amylin-based approaches, addressing both energy intake (via satiety) and energy expenditure simultaneously
Nevertheless, further studies are needed to determine the optimal order and regimen of incretin-based therapies in the management of pasireotide-induced hyperglycemia
