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Swelling and induration Swelling at the injection site can range from subtle puffiness to a firm, raised area several centimeters across
Therefore, compounds inhibiting the accumulation of senescent cells have become the subject of intensive research, especially for their potential application in treating diseases such as ischemic heart disease, Alzheimers disease, diabetes, atherosclerosis, or degenerative joint disease [98]
Experiments are designed to quantify its effects on collagen I and III synthesis (via qPCR or Western blot), myofibroblast differentiation (by measuring -smooth muscle actin expression), and the critical MMP/TIMP balance
Neurological recovery can be slow and incomplete, but stability is reassuring
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