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However, in glutathione synthetase deficiency, because the activity of gamma-glutamyl-cysteine synthetase is regulated via feedback inhibition by glutathione, gamma-glutamyl-cysteine and then L-5-oxoproline are overproduced, resulting in the metabolic acidosis and urinary excretion of this compound at levels several hundred-fold above normal (71
This gives us a very strong rational for using the Gymnema herbal over a very long period of time
A: A clinical difference must be a change to the formulation that produces a significant difference for the specific patient, as determined and documented by the prescriber
Clinical trials have also indicated that this form of treatment is relatively safe and tolerable when used in appropriate doses
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