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Limit or avoid caffeine (coffee, tea, energy drinks) on the day of treatment, if possible, as they may cause dehydration

Moreover, evidence supporting EGCGs neuroprotective effects via BBB-mediated anti-neuroinflammation and reduction of oxidative stress includes: (i) EGCG enhances dopamine neuron activity in the gut, decreases serotonin levels in the colon, and increases hippocampal 5-hydroxytryptamine levels by enhancing intestinal permeability (215217)

Interestingly, while the exposure of brain microvascular endothelial cells to the HIV-1 Tat protein leads to decreased expression of claudin-1, claudin-5, and ZO-2, the expression of ZO-1 and occludin remains unchanged [186]