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They include issues such as poor appetite, diarrhea, lethargy, weight loss, poor coat quality, and neurological problems
In clinical trials, doses are escalated gradually over several weeks to improve tolerability a process known as dose titration
Goodman et al., 2009) and experiments conducted on rodents (Lotocki et al., 2009
PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega- O -acylceramide synthesis and skin permeability barrier
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