what's glp-1 vs. GLP-1 + GIP: the Difference for your Metabolism? GLP-1 | Summary

Biological plausibility and experimental findings are not the same thing as proven clinical benefit

Xu H, Hiraishi K, Kurahara LH, Nakano-Narusawa Y, Li X, Hu Y, Matsuda Y, Zhang H, Hirano K (2021) Inhibitory effects of breast milk-derived Lactobacillus rhamnosus Probio-M9 on colitis-associated carcinogenesis by restoration of the gut microbiota in a mouse model

Because healthy proliferating cells do not rely on sustained FOXO4p53 sequestration for survival, they are less affected in experimental models

This can be done using stressful situations or by injecting lipopolysaccharide, an endotoxin from bacteria.[ref] Animals bred not to produce IL-6 are resistant to despair behavior usually induced by stress.[ref] Genetic studies in humans also link higher levels of IL-6, stressful life events, and an increased risk of depression.[ref] Interleukin-6 is one of the major cytokines released by immune cells in response to a pathogen or toxin