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The importance of mGSH is mainly based on its detoxification of hydrogen peroxide, mitochondrial lipid membrane peroxidation, or xenobiotics under the catalysis of enzymes such as GPX or GST [58]

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NRF2 activity is also increased by stress associated chemicals, such as NO, Zn 2+ , and alkenals (a class of carbonyls produced by lipid peroxidation) through their interaction with KEAP1 [195]