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Table A : GLP-1RAs versus other glucose-lowering agents: key specific features that impact treatment choice Given that there are few head-to-head studies comparing glucose-lowering effects between different drug classes, and the difficulty involved in performing cross-study comparisons due to different patient characteristics and baseline HbA 1c levels, there is widespread consensus that GLP-1RAs are more efficacious at lowering blood glucose than either DPP-IVs or SGLT-2 inhibitors

The metabolic improvements associated with GLP-1 agonist therapyincluding weight loss, improved glycaemic control, and potential benefits in MASLD (formerly known as non-alcoholic fatty liver disease)could address multiple health concerns simultaneously, though effects specifically in alcohol-related liver disease are not established

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