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L.HoekA.collaborators of the Dutch Multidisciplinary Guideline Development Group on Cardiovascular Risk Management after Reproductive Disorders (2016)

In their study, titled Depressive state and chronic fatigue in multiple sclerosis and neuromyelitis optica, published in the Journal of Neuroimmunology , researchers decided to study depression, fatigue and the use of l-carnitine in seventy-five patients with MS and 39 patients with NMO at Tohoku University Hospital in Japan

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However, these findings were not statistically significant ( p =0.546)