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Development of a sustained delivery for LH-RH analogs Since daily injections of LH-RH analogs were inconvenient and occasionally produced compliance problems, in 1984 we developed a long-acting delivery system for the agonist [d-Trp6]-LH-RH in microcapsules of poly (DL-lactide-co-glycolide) (PLG) designed to release a controlled dose of the peptide over a 30-day period 15