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Hormonal therapy resistance Primary endocrine resistance in breast cancer is often associated with the loss of estrogen receptor (ER) expression, while the aberrant activation of bypass signaling pathways and mutations in the gene encoding ER constitute key mechanisms of acquired resistance (Fig
Improved Sleep Quality Growth hormone is naturally released in deep sleepespecially during slow-wave cycles
Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps
Chronic insomnia can worsen depression, anxiety, irritability, impulsivity, pain sensitivity and attention
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