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Unlike human growth hormone (hGH), AOD-9604 does not alter insulin resistance or carbohydrate metabolism
AOD-9604 monotherapy produced about 2.6 kg of additional weight loss over placebo in a 12 week trial
By reducing insulin resistance, Naltrexone aids in weight loss and helps lower androgen levels in women with PCOS, reducing symptoms such as excessive hair growth and depression
Furthermore, exercise increases reactive oxygen species (ROS) levels through various mechanisms and then triggers the activation of Nrf2 9,10 .MOTS-c is an open reading frame peptide encoded by a mitochondrial 12 s rRNA gene 11 , which mainly targets muscle tissue, significantly enhances insulin sensitivity, and improves glucose utilization 12,13
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