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For GIP-bound GIPR, the C-terminal residues of GH5 (L388, Y391, L393, and L394) insert into a hydrophobic pocket (formed by L241 3.54b , L244 3.57b , L321 5.61b , and L325 5.65b ), and L394 GH5 makes one hydrogen bond with the side chain of R338 6.37b

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Indeed, the underlying mechanisms of these drugs on the CV system are not definitively understood