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The pharmacokinetic rationale Semaglutide has a half-life of approximately 7 days, which is what allows for once-weekly dosing

Successful examples include semaglutide (168h), an oral octreotide formulation (restricted maintenance indication), and emerging candidates such as I-338 insulin (60h), which used sodium caprate (C10) in Novo Nordisks Phase II, trials ( 7.1 Application to FDA-approved and emerging peptides Table 2 applies this framework to representative FDA-approved peptides and emerging candidates, demonstrating how few molecules meet the criteria for oral feasibility and why the historical record of failure is the expected outcome rather than a surprising result

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