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The Optimal Timing Protocol: Start supporting your mast cells and histamine pathways 4-6 weeks BEFORE your symptoms typically begin to support a healthy foundation ahead of time Continue throughout your challenging season Maintain foundational support (gut health, methylation, vitamin D, sleep) year-round Think about it like this: you don't wait until your house is on fire to install smoke detectors

To minimise gastrointestinal risks: Take ibuprofen with or after food Use the lowest effective dose for the shortest duration necessary Avoid exceeding 1,200 mg daily (for over-the-counter use) unless advised by a clinician Consider gastric protection (e.g., proton pump inhibitors) if prolonged use is necessary or if risk factors for peptic ulceration exist, as per NICE guidance Maintain good hydration, particularly if experiencing Wegovy-related gastrointestinal effects Special considerations apply to certain groups: Pregnancy and breastfeeding : Ibuprofen should be avoided during pregnancy, particularly after 20 weeks, unless specifically advised by a doctor

As we learn more about these medications, its becoming clear that they can be helpful for people with other health conditions