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Conversely, either germline knockout or antisense oligonucleotide knockdown of FGFR4 expression in mice enhances hepatic fat oxidation, glucose metabolism, and insulin sensitivity (308310) while reducing hepatic steatosis (308, 309)
ANGPTL4 The ANGPTL4 gene was initially identified as a gene induced during periods of fasting and also as a result of its induction by peroxisome proliferator-activated receptor- (PPAR) in white adipose tissue (WAT)
In practice, many protocols do not treat this as an either/or decision at all, and instead combine the two mechanisms a point covered in the next section
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