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Some preclinical studies suggest that GLP-1 receptor stimulation may have anti-inflammatory and neuroprotective properties that could improve mood over time
However, in AP/CP there is marked increase in GLP-1R, primarily in PSCs
Data on long-term side effects of Wegovy are still developing, but current evidence suggests that Wegovy is generally well tolerated
Patients with obesity may exhibit variable HPA axis patterns, with some studies showing alterations in 24-hour urinary cortisol excretion despite normal serum cortisol levels, though these findings are heterogeneous across studies
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