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Who is not a good candidate for GLP-1
Liraglutide (daily) is an established shorter-acting option
However, GLP-1 receptor knockout mice do not become obese [88], and deletion of the mouse Gcg gene (encoding GLP-1) from the entire intestine, resulting in a 90% reduction of circulating GLP-1, does not perturb food intake or weight gain [89]
GLP-1 medicines may increase the risk of gallbladder problems, including gallstones and gallbladder inflammation
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