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This isn't just about the medication being "a little less effective." When protein drugs aggregate, they can become significantly less potent and in some cases, these protein clumps might even trigger immune reactions in your body
The p Ka of the putative catalytic cysteine is lower in GRXC2 than in ROXY9 To investigate the potential reactivity of Cys A of ROXY9 and GRXC2 as a nucleophile under physiological p H , we compared the apparent p K a values of the cysteines of strep-MBP-ROXY9 and strep-MBP-GRXC2
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