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The red arrows in Figure 1 show what we call long-range interactions, in which substrates allosterically affect distant enzymes in the network

Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 microm size X-ray synchrotron beam

To evaluate Dihexas ability to cross the BBB and accumulate in brain regions, rats were fitted with carotid cannulas and infused with a mixture of [H]Dihexa (10 Ci) and [C]inulin (2 Ci), a vascular space marker, in 100 l of isotonic saline

By moving gradually from 2 mg to higher doses, the trial sponsors could keep dropout rates low while still pushing toward therapeutically meaningful levels