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Most patients see improvement after the initial adjustment phase, but close monitoring with dilated eye exams and retinal imaging is critical during this window
Activation of GPR41 increases the secretion of intestinal peptide YY (PYY) and decreases the secretion of glucose-dependent insulin-releasing polypeptide (GIP) and growth hormone-releasing peptide, thereby reducing glucose uptake (Hu et al., 2018)
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Novo Nordisk tried a different approach: IL6 inhibition, in people with atherosclerotic cardiovascular disease, chronic kidney disease and inflammation (high levels of hsCRP)
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