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At the category level, mild localized skin redness or itching at the application site is the most commonly reported issue with adhesive patches of any kind - this typically comes from the adhesive material, not the botanical ingredients themselves

Does not elevate IGF-1 levels or cause insulin resistance

Environ Health Perspect 108(1):4553 Muhammadamin KY, Darweesh OO, Alshawni MA (2011) Evaluation of testosterone hormone and zinc levels among infertile males in Kirkuk province/Iraq