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Adverse reactions leading to discontinuation of therapy were predominantly gastrointestinal
doi: 68
If you need an isotonic solution one that matches the body's natural salt balance or you're working with a compound where preservative-free saline is specifically recommended, saline is the appropriate choice
The glutaminase activity of L-asparaginase is not required for anti-cancer activity against ASNS-negative cancer cells, therefore there have been attempt for purifying glutaminase-free L-asparaginase from other sources or engineering L-asparaginase to be glutaminase-free [96, 97]
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