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R 4-OH catechol estrogens that are not methylated by COMT can be oxidized to quinones that generate reactive oxygen species and form DNA adducts, a mechanism implicated in estrogen-dependent cancers
Notably, exercise training improves EC-dependent vasodilation in elderly patients with CAD, in part by activating eNOS [195]
Women with pernicious anemia should work closely with a provider before and during pregnancy to ensure adequate B12 support
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