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Because orforglipron is a small molecule, it doesnt require the complex biological manufacturing or cold-chain logistics that peptide drugs like semaglutide demand
However, this was predominantly driven by one trial, DECLARE TIMI 58, which included healthier cohorts than other cardiovascular outcome trials (CVOT) involving SGLT-2 inhibitors [103], and this benefit of asthma risk reduction was neutralized when DECLARE TIMI 58 was excluded from the analysis [105]
The same principles apply to tirzepatide and retatrutide, though specific guidelines for retatrutide will not exist until it reaches the market
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