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For example, orally administered probiotic Lactobacillus rhamnosus GG (LGG) targets infiltrated PDAC via the gutpancreas axis and, using a surface-engineered gallium-polyphenol (Ga-poly) network, modulates intratumoral microbiota and reshapes the immune microenvironment

Important safety considerations include the risk of pancreatitis (all GLP-1 agonists carry warnings about this), gallbladder disease (more common with greater weight loss), and a caution with semaglutide in patients with pre-existing diabetic retinopathy, where rapid improvement in glucose control may temporarily worsen retinopathy

The guidelines aim to provide the most current, scientifically backed recommendations for diabetes care

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