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Patients with a history of pancreatitis should be evaluated carefully before initiating treatment with Semaglutide / Cyanocobalamin Injection, as GLP-1 receptor agonists have been associated with acute pancreatitis in post-marketing surveillance, though a definitive causal relationship has not been established

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The Zepbound FDA prescribing information also carries a boxed warning for thyroid C-cell tumors based on rat studies

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10.1177/0022034517728504 123 QiaoY.LiuX.ZhouX.ZhangH.ZhangW.XiaoW.et al (2020)

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Sermorelin, also a GHRH analog, was once FDA-approved for pediatric GH deficiency but is no longer marketed

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