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Complementary evidence from national registry analyses shows that obesity frequently precedes the onset of a wide spectrum of psychiatric disorders [4], while Mendelian randomization studies provide converging support for a causal pathway from higher BMI to depression [18]

The reference lists from published articles and trials were manually retrieved and screened to identify relevant additional studies

The team found the most common factor influencing the likelihood of discontinuation was age, with younger users aged 1829 years 48 percent more likely to stop treatment within the first year than those aged 4559 years

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