Gastroenterology 132, 21312157, doi: 10.1053/j.gastro.2007.03.054 (2007)
How Your Body Makes GLP-1 Naturally GLP-1 is produced primarily in the intestinal tract, especially after nutrients enter the gut
Research shows clear benefits: Better stability than oral delivery, which exposes peptides to harsh stomach conditions Less breakdown by enzymes that would destroy the peptide before it reaches the blood Easier compliance no needles, no mixing, just spray Potential for targeted delivery to specific tissues, including the brain via the olfactory pathway Nasal delivery works very well for peptides like BPC-157 that target the whole body
External resources For researchers serious about understanding the full landscape of weight loss medications and making informed decisions about peptide-based treatments, SeekPeptides provides the most comprehensive resource available, with evidence-based guides, detailed comparison tools, and a community of thousands who have navigated these exact questions