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Diabetologia 52:12401249 Acknowledgements This work was funded by The Health Research Board of Ireland and Enterprise Ireland, as well as by The State of So Paulo Research Foundation (FAPESP), the Programme for support for centres of excellence PRONEX and the National Council for Scientific and Technological Development (CNPq), Brazil

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There are two 2HG enantiomers: D-2-hydroxyglutarate (D2HG) and L-2-hydroxyglutarate (L2HG), with the former predominantly generated from IDH1 mutants and PHGDH while L2HG is primarily generated from the promiscuous activity of LDHA and MDH1/2 under hypoxic or acidic conditions and converted back to 2OG by L2HGDH

Glutathione Is Naturally Present in the Body Glutathione is already naturally present in the body, including in the placenta